Effects of Melatonin on the Body Composition, Physical Performance, and Blood Erythrocyte Indexes of C57Bl/6J Mice Exposed to Continuous Illumination
- Авторы: Michurina S.1, Ishchenko I.1, Korolev M.1, Letyagin A.1,2, Rachkovskaya L.1, Khotskina A.2, Khotskin N.2, Maslennikova S.2, Zavjalov E.2
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Учреждения:
- Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Выпуск: Том 168, № 1 (2019)
- Страницы: 28-32
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242175
- DOI: https://doi.org/10.1007/s10517-019-04638-2
- ID: 242175
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Аннотация
Male C57Bl/6J mice were exposed to daily 24-h illumination over 14 days and daily intragastrically received melatonin (1 mg/kg) or water (placebo). Controls were kept under standard day/night (14/10 h) conditions. Melatonin prevented the development of anemia in mice exposed to continuous illumination, which was proven by higher blood hemoglobin levels by the end of the experiment in melatonin-treated animals in comparison with the placebo group. Studies by the low-field NMR spectrometry detected lower lean body mass, total body water, and especially, fat content (by ~13%) in animals receiving placebo. Melatonin treatment led to an increase in the lean body mass and total body water on day 7 (in comparison with the placebo group) without affecting fat mass. On day 14 of continuous illumination, lean body mass increased in comparison with the corresponding parameter in the control and placebo groups. Melatonin had no effect on the physical endurance of mice exposed to continuous illumination (assessed by the grid hanging test).
Об авторах
S. Michurina
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: s.michurina@ngs.ru
Россия, Novosibirsk
I. Ishchenko
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Россия, Novosibirsk
M. Korolev
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Россия, Novosibirsk
A. Letyagin
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Россия, Novosibirsk; Novosibirsk
L. Rachkovskaya
Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Россия, Novosibirsk
A. Khotskina
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Россия, Novosibirsk
N. Khotskin
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Россия, Novosibirsk
S. Maslennikova
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Россия, Novosibirsk
E. Zavjalov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: s.michurina@ngs.ru
Россия, Novosibirsk