电邮这篇文章 Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff
- 作者: Ziyatdinova N.1, Kuptsova A.1, Faskhutdinov L.1, Galieva A.1, Zefirov A.2, Zefirov T.1
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隶属关系:
- Department of Human Health Protection, Kazan (Volga region) Federal University
- Department of Normal Physiology, Kazan Federal Medical University
- 期: 卷 167, 编号 4 (2019)
- 页面: 424-427
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241775
- DOI: https://doi.org/10.1007/s10517-019-04541-w
- ID: 241775
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详细
The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10—9 M decreased HR by 26.8% (p≤0.05). In concentrations 10—8, 10—7, 10—6, and 10—5 M ZD7288 produced minor differently directed effects. In a concentration of 10—5 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In other concentrations, the blocker produced no significant effects on coronary flow.
作者简介
N. Ziyatdinova
Department of Human Health Protection, Kazan (Volga region) Federal University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
A. Kuptsova
Department of Human Health Protection, Kazan (Volga region) Federal University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
L. Faskhutdinov
Department of Human Health Protection, Kazan (Volga region) Federal University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
A. Galieva
Department of Human Health Protection, Kazan (Volga region) Federal University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
A. Zefirov
Department of Normal Physiology, Kazan Federal Medical University
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan, the republic of Tatarstan
T. Zefirov
Department of Human Health Protection, Kazan (Volga region) Federal University
编辑信件的主要联系方式.
Email: zefirovtl@mail.ru
俄罗斯联邦, Kazan
