Effect of If Current Blockade on Newborn Rat Heart Isolated According to Langendorff
- Authors: Ziyatdinova N.I.1, Kuptsova A.M.1, Faskhutdinov L.I.1, Galieva A.M.1, Zefirov A.L.2, Zefirov T.L.1
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Affiliations:
- Department of Human Health Protection, Kazan (Volga region) Federal University
- Department of Normal Physiology, Kazan Federal Medical University
- Issue: Vol 167, No 4 (2019)
- Pages: 424-427
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241775
- DOI: https://doi.org/10.1007/s10517-019-04541-w
- ID: 241775
Cite item
Abstract
The study examined the effects of hyperpolarization-activated funny current (If) on HR and coronary flow in Langendorff-isolated hearts from newborn rats. Blockade of If current with ZD7288 changed the examined cardiac parameters. The blocker in a concentration of 10—9 M decreased HR by 26.8% (p≤0.05). In concentrations 10—8, 10—7, 10—6, and 10—5 M ZD7288 produced minor differently directed effects. In a concentration of 10—5 M, ZD7288 reduced coronary flow in the isolated heart (p≤0.01). In other concentrations, the blocker produced no significant effects on coronary flow.
About the authors
N. I. Ziyatdinova
Department of Human Health Protection, Kazan (Volga region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
A. M. Kuptsova
Department of Human Health Protection, Kazan (Volga region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
L. I. Faskhutdinov
Department of Human Health Protection, Kazan (Volga region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
A. M. Galieva
Department of Human Health Protection, Kazan (Volga region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
A. L. Zefirov
Department of Normal Physiology, Kazan Federal Medical University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the republic of Tatarstan
T. L. Zefirov
Department of Human Health Protection, Kazan (Volga region) Federal University
Author for correspondence.
Email: zefirovtl@mail.ru
Russian Federation, Kazan