A Combination of Muramylpeptides from Gram-Negative Bacteria Corrects Hematological and Immunological Disorders Induced by Cyclophosphamide
- 作者: Kiselevskii M.1, Anisimova N.1, Sitdikova S.1, Donenko F.1, Popilyuk S.2, L’vov V.3, Kalyuzhin O.4
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隶属关系:
- Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center, Ministry of Health of the Russian Federation
- CORUS Pharma Company, Resident of Biomedical Technologies Cluster, Skolkovo Foundation
- Laboratory No. 16 for Preparatory Biochemistry of Antigens, State Research Center Institute of Immunology, Federal Medial-Biological Agency
- Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
- 期: 卷 167, 编号 3 (2019)
- 页面: 371-374
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241704
- DOI: https://doi.org/10.1007/s10517-019-04529-6
- ID: 241704
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详细
We have studied the effect of a combination of three natural muramylpeptides containing a meso-diaminopimelic acid residue (polyramyl) on the subpopulations of circulating T cells, spleen morphology, and leukocyte level in the blood of C57Bl/6 mice with cyclophosphamideinduced immunosuppression. Intraperitoneal injections of cyclophosphamide in a dose of 100 mg/kg on days 1, 3, 5, and 7 of the experiment reduced leukocyte count and the relative number of CD4+ T cells in the blood, and also depleted the cellular composition of splenic white pulp on day 10. Subcutaneous injections of polyramyl in a dose of 200 μg/mouse on days 8 and 9 practically completely restored blood leukocytes count and morphology of the splenic white pulp. Moreover, administration of polyramyl induced marked tendency to increase in the relative number of CD4+ T cells and CD4/CD8 ratio in mice with cyclophosphamideinduced immunosuppression.
作者简介
M. Kiselevskii
Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: kisele@inbox.ru
俄罗斯联邦, Moscow
N. Anisimova
Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center, Ministry of Health of the Russian Federation
Email: kisele@inbox.ru
俄罗斯联邦, Moscow
S. Sitdikova
Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center, Ministry of Health of the Russian Federation
Email: kisele@inbox.ru
俄罗斯联邦, Moscow
F. Donenko
Laboratory of Cellular Immunity, N. N. Blokhin National Medical Research Center, Ministry of Health of the Russian Federation
Email: kisele@inbox.ru
俄罗斯联邦, Moscow
S. Popilyuk
CORUS Pharma Company, Resident of Biomedical Technologies Cluster, Skolkovo Foundation
Email: kisele@inbox.ru
俄罗斯联邦, Skolkovo, Moscow Region
V. L’vov
Laboratory No. 16 for Preparatory Biochemistry of Antigens, State Research Center Institute of Immunology, Federal Medial-Biological Agency
Email: kisele@inbox.ru
俄罗斯联邦, Volokolamsk
O. Kalyuzhin
Department of Clinical Immunology and Allergology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation
Email: kisele@inbox.ru
俄罗斯联邦, Moscow