Store-Operated Calcium Entry in Mouse Cardiomyocytes
- 作者: Gusev K.1, Vigont V.1, Grekhnev D.1, Shalygin A.1, Glushankova L.1, Kaznacheeva E.1
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隶属关系:
- Department of Ion Channels of Cell Membranes, Institute of Cytology, Russian Academy of Science
- 期: 卷 167, 编号 3 (2019)
- 页面: 311-314
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241672
- DOI: https://doi.org/10.1007/s10517-019-04516-x
- ID: 241672
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详细
The fluorescent dye fura-2 AM was employed to record activation of Ca2+ entry in response to a decrease in Ca2+ concentration in the endoplasmic reticulum. Using whole-cell voltage clamp technique, we revealed Ca2+ currents with an amplitude of 0.46±0.13 pA/pF that passed through selective channels with current-voltage characteristics similar to those of classical store-operated CRAC channels. These currents were sensitive to 2-APB (50 μM), an inhibitor of store-operated channels. The data suggest that store-operated calcium entry is a characteristic feature of mature ventricular cardiomyocytes. Pathological alterations in store-operated Ca2+ entry can be implicated in the development of heart diseases.
作者简介
K. Gusev
Department of Ion Channels of Cell Membranes, Institute of Cytology, Russian Academy of Science
编辑信件的主要联系方式.
Email: k.o.gusev@gmail.com
俄罗斯联邦, St. Petersburg
V. Vigont
Department of Ion Channels of Cell Membranes, Institute of Cytology, Russian Academy of Science
Email: k.o.gusev@gmail.com
俄罗斯联邦, St. Petersburg
D. Grekhnev
Department of Ion Channels of Cell Membranes, Institute of Cytology, Russian Academy of Science
Email: k.o.gusev@gmail.com
俄罗斯联邦, St. Petersburg
A. Shalygin
Department of Ion Channels of Cell Membranes, Institute of Cytology, Russian Academy of Science
Email: k.o.gusev@gmail.com
俄罗斯联邦, St. Petersburg
L. Glushankova
Department of Ion Channels of Cell Membranes, Institute of Cytology, Russian Academy of Science
Email: k.o.gusev@gmail.com
俄罗斯联邦, St. Petersburg
E. Kaznacheeva
Department of Ion Channels of Cell Membranes, Institute of Cytology, Russian Academy of Science
Email: k.o.gusev@gmail.com
俄罗斯联邦, St. Petersburg