Particularities of Bone Regeneration in Rats after Implantation of Polycaprolactone Scaffold Mineralized with Vaterite with Adsorbed Tannic Acid
- 作者: Gladkova E.1, Blinnikova V.1, Babushkina I.1, Parakhonskiy B.1, Ulyanov V.1, Norkin I.1, Ivanov A.1, Saveleva M.1, Kurtukova M.1, Kustodov S.1
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隶属关系:
- Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
- 期: 卷 167, 编号 2 (2019)
- 页面: 275-278
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241638
- DOI: https://doi.org/10.1007/s10517-019-04508-x
- ID: 241638
如何引用文章
详细
We studied the particularities of osteo- and angiogenesis in albino rats after implantation of polycaprolactone scaffolds mineralized with vaterite with adsorbed tannic acid in the femoral bone defect. It was found that the processes of angio- and osteogenesis in the bone tissue after scaffolds implantation depend on their biocompatibility. Implantation of non-biocompatible scaffolds was followed by activation of angio- and osteogenesis aimed at separation of these scaffold from surrounding tissues. Implantation of polycaprolactone/vaterite scaffolds containing tannic acid stimulated angio- and osteogenesis leading to vascularization and bone tissue formation in the matrix. This demonstrate prospects of clinical approbation of these scaffolds for stimulation of bone regeneration in traumatological and orthopedic patients.
作者简介
E. Gladkova
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
V. Blinnikova
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
I. Babushkina
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
B. Parakhonskiy
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
V. Ulyanov
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
I. Norkin
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
A. Ivanov
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
M. Saveleva
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
M. Kurtukova
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov
S. Kustodov
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
俄罗斯联邦, Saratov