Email this article Particularities of Bone Regeneration in Rats after Implantation of Polycaprolactone Scaffold Mineralized with Vaterite with Adsorbed Tannic Acid
- Authors: Gladkova E.V.1, Blinnikova V.V.1, Babushkina I.V.1, Parakhonskiy B.V.1, Ulyanov V.Y.1, Norkin I.A.1, Ivanov A.N.1, Saveleva M.S.1, Kurtukova M.O.1, Kustodov S.V.1
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Affiliations:
- Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 167, No 2 (2019)
- Pages: 275-278
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241638
- DOI: https://doi.org/10.1007/s10517-019-04508-x
- ID: 241638
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Abstract
We studied the particularities of osteo- and angiogenesis in albino rats after implantation of polycaprolactone scaffolds mineralized with vaterite with adsorbed tannic acid in the femoral bone defect. It was found that the processes of angio- and osteogenesis in the bone tissue after scaffolds implantation depend on their biocompatibility. Implantation of non-biocompatible scaffolds was followed by activation of angio- and osteogenesis aimed at separation of these scaffold from surrounding tissues. Implantation of polycaprolactone/vaterite scaffolds containing tannic acid stimulated angio- and osteogenesis leading to vascularization and bone tissue formation in the matrix. This demonstrate prospects of clinical approbation of these scaffolds for stimulation of bone regeneration in traumatological and orthopedic patients.
About the authors
E. V. Gladkova
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
V. V. Blinnikova
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
I. V. Babushkina
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
B. V. Parakhonskiy
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
V. Yu. Ulyanov
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
I. A. Norkin
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
A. N. Ivanov
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: lex558452@gmail.com
Russian Federation, Saratov
M. S. Saveleva
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
M. O. Kurtukova
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
S. V. Kustodov
Research Institute of Traumatology, Orthopaedics, and Neurosurgery, V. I. Razumovsky Saratov State Medical University, Ministry of Health of the Russian Federation
Email: lex558452@gmail.com
Russian Federation, Saratov
