Enviar artigo por via de e-mail Effects of Cocarboxylase in Amikacin-Induced Ototoxicity in Immature Animals
- Autores: Ischanova Y.S.1, Rakhmanova I.V.1, D’yakonova I.N.2
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Afiliações:
- Research Laboratory of Experimental Pediatric Otolaryngology
- Department of Physiology, Medical-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- Edição: Volume 167, Nº 2 (2019)
- Páginas: 250-254
- Seção: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/241626
- DOI: https://doi.org/10.1007/s10517-019-04502-3
- ID: 241626
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Resumo
Possible otoprotective properties of cocarboxylase were studied on the model of amikacin-induced ototoxicity in immature rabbits. Auditory function was evaluated by the short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE) tests. Administration of cocarboxylase after modeling of amikacin-induced ototoxicity resulted in a decrease in the ABR peak I threshold and prevented damage to the outer hair cells.
Sobre autores
Yu. Ischanova
Research Laboratory of Experimental Pediatric Otolaryngology
Autor responsável pela correspondência
Email: ischanova@hotmail.com
Rússia, Moscow
I. Rakhmanova
Research Laboratory of Experimental Pediatric Otolaryngology
Email: ischanova@hotmail.com
Rússia, Moscow
I. D’yakonova
Department of Physiology, Medical-Biological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: ischanova@hotmail.com
Rússia, Moscow
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