The Structure of NO-Mediated Dilatation of Pulmonary Arteries Depends on NO Availability
- 作者: Davydova M.1
-
隶属关系:
- Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
- 期: 卷 167, 编号 2 (2019)
- 页面: 247-249
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241618
- DOI: https://doi.org/10.1007/s10517-019-04501-4
- ID: 241618
如何引用文章
详细
NO-mediated vasodilatation can be realized via two pathways: dependent and independent on soluble guanylate cyclase; the latter is implemented through NO interaction with ionic channels. We evaluated the contribution of these pathways into NO-induced relaxation of isolated pulmonary arteries in rats. In pulmonary arteries, in contrast to systemic vessels, soluble guanylate cyclase-independent mechanisms is more important, because it mediates relaxation in response to low concentrations of NO donor. The role of soluble guanylate cyclase-dependent mechanisms in the mechanisms of vasodilatation increases with increasing NO donor concentrations.
作者简介
M. Davydova
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: dawydova2015@gmail.com
俄罗斯联邦, Moscow