The Structure of NO-Mediated Dilatation of Pulmonary Arteries Depends on NO Availability
- Autores: Davydova M.1
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Afiliações:
- Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
- Edição: Volume 167, Nº 2 (2019)
- Páginas: 247-249
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241618
- DOI: https://doi.org/10.1007/s10517-019-04501-4
- ID: 241618
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Resumo
NO-mediated vasodilatation can be realized via two pathways: dependent and independent on soluble guanylate cyclase; the latter is implemented through NO interaction with ionic channels. We evaluated the contribution of these pathways into NO-induced relaxation of isolated pulmonary arteries in rats. In pulmonary arteries, in contrast to systemic vessels, soluble guanylate cyclase-independent mechanisms is more important, because it mediates relaxation in response to low concentrations of NO donor. The role of soluble guanylate cyclase-dependent mechanisms in the mechanisms of vasodilatation increases with increasing NO donor concentrations.
Sobre autores
M. Davydova
Faculty of Fundamental Medicine, M. V. Lomonosov Moscow State University
Autor responsável pela correspondência
Email: dawydova2015@gmail.com
Rússia, Moscow