Collagen Peptides from Hyaline Cartilage for the Treatment and Prevention of Joint Diseases: Isolation and Characteristics
- 作者: Nikolaeva T.1, Laurinavicius K.2, Kaptsov V.3, Chernyi R.4, Shekhovtsov P.1
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隶属关系:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences
- Institute of Cell Biophysics, Russian Academy of Sciences
- P. N. Lebedev Physical Institute
- 期: 卷 167, 编号 2 (2019)
- 页面: 242-246
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241615
- DOI: https://doi.org/10.1007/s10517-019-04500-5
- ID: 241615
如何引用文章
详细
We studied the effects of Chymopsin and Caripazim on the proteolysis of collagen proteins from cattle tracheal hyaline cartilage. Homogenization of the cartilage under conditions of high pressure and temperature facilitated subsequent enzymatic hydrolysis: the degree of hydrolysis increased upon elevation of pressure from 40 to 80 mPa and temperature from 60 to 70°C. Proteolysis with Chymopsin yielded collagen peptides with molecular weights from 900 to 7000 Da, while Caripazim processing yielded collagen peptides with lower molecular weights from 250 to 780 Da consisting of 2-8 amino acids, which could be easily absorbed and intensely incorporated in the formation of the joint tissue structures.
作者简介
T. Nikolaeva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: tomivnik@yandex.ru
俄罗斯联邦, Moscow
K. Laurinavicius
G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences
Email: tomivnik@yandex.ru
俄罗斯联邦, Moscow
V. Kaptsov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: tomivnik@yandex.ru
俄罗斯联邦, Moscow Region, Pushchino
R. Chernyi
P. N. Lebedev Physical Institute
Email: tomivnik@yandex.ru
俄罗斯联邦, Moscow
P. Shekhovtsov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: tomivnik@yandex.ru
俄罗斯联邦, Moscow
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