Collagen Peptides from Hyaline Cartilage for the Treatment and Prevention of Joint Diseases: Isolation and Characteristics
- Авторлар: Nikolaeva T.1, Laurinavicius K.2, Kaptsov V.3, Chernyi R.4, Shekhovtsov P.1
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Мекемелер:
- Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
- G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences
- Institute of Cell Biophysics, Russian Academy of Sciences
- P. N. Lebedev Physical Institute
- Шығарылым: Том 167, № 2 (2019)
- Беттер: 242-246
- Бөлім: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241615
- DOI: https://doi.org/10.1007/s10517-019-04500-5
- ID: 241615
Дәйексөз келтіру
Аннотация
We studied the effects of Chymopsin and Caripazim on the proteolysis of collagen proteins from cattle tracheal hyaline cartilage. Homogenization of the cartilage under conditions of high pressure and temperature facilitated subsequent enzymatic hydrolysis: the degree of hydrolysis increased upon elevation of pressure from 40 to 80 mPa and temperature from 60 to 70°C. Proteolysis with Chymopsin yielded collagen peptides with molecular weights from 900 to 7000 Da, while Caripazim processing yielded collagen peptides with lower molecular weights from 250 to 780 Da consisting of 2-8 amino acids, which could be easily absorbed and intensely incorporated in the formation of the joint tissue structures.
Авторлар туралы
T. Nikolaeva
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: tomivnik@yandex.ru
Ресей, Moscow
K. Laurinavicius
G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences
Email: tomivnik@yandex.ru
Ресей, Moscow
V. Kaptsov
Institute of Cell Biophysics, Russian Academy of Sciences
Email: tomivnik@yandex.ru
Ресей, Moscow Region, Pushchino
R. Chernyi
P. N. Lebedev Physical Institute
Email: tomivnik@yandex.ru
Ресей, Moscow
P. Shekhovtsov
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences
Email: tomivnik@yandex.ru
Ресей, Moscow
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