Neurodegenerative Changes in Rat Brain in Streptozotocin Model of Alzheimer’s Disease
- 作者: Voronkov D.1, Stavrovskaya A.1, Stelmashook E.1, Genrikhs E.1, Isaev N.1,2
-
隶属关系:
- Research Center of Neurology
- A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
- 期: 卷 166, 编号 6 (2019)
- 页面: 793-796
- 栏目: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/241372
- DOI: https://doi.org/10.1007/s10517-019-04442-y
- ID: 241372
如何引用文章
详细
One of the most common models of sporadic form of Alzheimer’s disease is injection of streptozotocin into the lateral ventricles of rat brain. In 3 months after this injection, an increase in the expression of astroglia in the corpus callosum and a decrease in the thickness of the corpus callosum and intensity of its staining with luxol fast blue were observed. This can reflect a decrease in the content of myelinated fibers. In layer V of the sensorimotor cortex, intensive degeneration of neurons was revealed. The lateral ventricles were significantly enlarged and the expression of PSA-NCAM protein, a marker of immature neurons, was reduced in subventricular zone, which can be associated with disturbed neurogenesi
作者简介
D. Voronkov
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
A. Stavrovskaya
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
E. Stelmashook
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
E. Genrikhs
Research Center of Neurology
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow
N. Isaev
Research Center of Neurology; A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: isaev@genebee.msu.ru
俄罗斯联邦, Moscow; Moscow
![](/img/style/loading.gif)