Neurodegenerative Changes in Rat Brain in Streptozotocin Model of Alzheimer’s Disease
- Authors: Voronkov D.N.1, Stavrovskaya A.V.1, Stelmashook E.V.1, Genrikhs E.E.1, Isaev N.K.1,2
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Affiliations:
- Research Center of Neurology
- A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
- Issue: Vol 166, No 6 (2019)
- Pages: 793-796
- Section: Morphology and Pathomorphology
- URL: https://journals.rcsi.science/0007-4888/article/view/241372
- DOI: https://doi.org/10.1007/s10517-019-04442-y
- ID: 241372
Cite item
Abstract
One of the most common models of sporadic form of Alzheimer’s disease is injection of streptozotocin into the lateral ventricles of rat brain. In 3 months after this injection, an increase in the expression of astroglia in the corpus callosum and a decrease in the thickness of the corpus callosum and intensity of its staining with luxol fast blue were observed. This can reflect a decrease in the content of myelinated fibers. In layer V of the sensorimotor cortex, intensive degeneration of neurons was revealed. The lateral ventricles were significantly enlarged and the expression of PSA-NCAM protein, a marker of immature neurons, was reduced in subventricular zone, which can be associated with disturbed neurogenesi
About the authors
D. N. Voronkov
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
A. V. Stavrovskaya
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
E. V. Stelmashook
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
E. E. Genrikhs
Research Center of Neurology
Email: isaev@genebee.msu.ru
Russian Federation, Moscow
N. K. Isaev
Research Center of Neurology; A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: isaev@genebee.msu.ru
Russian Federation, Moscow; Moscow