Abnormal Membrane Localization of α2 Isoform of Na,K-ATPase in m. soleus of Dysferlin-Deficient Mice
- 作者: Kravtsova V.1, Bouzinova E.2, Machkov V.2, Timonina N.1, Zakyrjanova G.3,4, Zefirov A.4, Krivoi I.1
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隶属关系:
- Department of General Physiology, St. Petersburg State University
- Department of Biomedicine, Health, Aarhus University
- Kazan Institute of Biochemistry and Biophysics, Federal Research Center Kazan Scientific Center of the Russian Academy of Science
- Department of Normal Physiology, Kazan State Medical University
- 期: 卷 166, 编号 5 (2019)
- 页面: 593-597
- 栏目: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/241217
- DOI: https://doi.org/10.1007/s10517-019-04398-z
- ID: 241217
如何引用文章
详细
Dysferlin protein plays a key role in the multimolecular complex responsible for the maintenance of sarcolemma integrity and skeletal muscle cell functioning. We studied the membrane distribution of nicotinic acetylcholine receptors and α2 isoform of Na,K-ATPase in motor endplates of m. soleus in dysferlin-deficient Bla/J mice (a dysferlinopathy model). Endplates of Bla/J mice were characterized by increased area (without changes in fragmentation degree) and reduced density of the membrane distribution of nicotinic acetylcholine receptors in comparison with the corresponding parameters in control С57Bl/6 mice. The density of the membrane distribution of α2 isoform of Na,K-ATPase was also reduced, but the level of the corresponding mRNA remained unchanged. It can be hypothesized that abnormal membrane localization of α2 isoform of Na,K-ATPase results from adaptive skeletal muscle remodeling under conditions of chronic motor dysfunction.
作者简介
V. Kravtsova
Department of General Physiology, St. Petersburg State University
Email: iikrivoi@gmail.com
俄罗斯联邦, St. Petersburg
E. Bouzinova
Department of Biomedicine, Health, Aarhus University
Email: iikrivoi@gmail.com
丹麦, Aarhus
V. Machkov
Department of Biomedicine, Health, Aarhus University
Email: iikrivoi@gmail.com
丹麦, Aarhus
N. Timonina
Department of General Physiology, St. Petersburg State University
Email: iikrivoi@gmail.com
俄罗斯联邦, St. Petersburg
G. Zakyrjanova
Kazan Institute of Biochemistry and Biophysics, Federal Research Center Kazan Scientific Center of the Russian Academy of Science; Department of Normal Physiology, Kazan State Medical University
Email: iikrivoi@gmail.com
俄罗斯联邦, Kazan; Kazan, Tatarstan Republic
A. Zefirov
Department of Normal Physiology, Kazan State Medical University
Email: iikrivoi@gmail.com
俄罗斯联邦, Kazan, Tatarstan Republic
I. Krivoi
Department of General Physiology, St. Petersburg State University
编辑信件的主要联系方式.
Email: iikrivoi@gmail.com
俄罗斯联邦, St. Petersburg