Cytotoxic Activity of Peripheral Blood NK Cells towards Trophoblast Cells during Pregnancy
- 作者: Mikhailova V.1, Bazhenov D.1, Viazmina L.1, Agnaeva A.1, Bespalova O.1, Sel’kov S.1, Sokolov D.1
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隶属关系:
- D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
- 期: 卷 166, 编号 4 (2019)
- 页面: 567-573
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241191
- DOI: https://doi.org/10.1007/s10517-019-04393-4
- ID: 241191
如何引用文章
详细
We evaluated cytotoxic activity of peripheral blood NK cells towards trophoblast cells. NK cells either isolated or in the composition of mononuclear cell fraction, caused death of trophoblast cells. In women with physiological pregnancy, the cytotoxic effect of NK cells present in mononuclear cell fraction preincubated with IL-2 was lower than in nonpregnant women, who had never been pregnant previously, and in fertile women. Cytotoxic activity of isolated NK cells preincubated with IL-2 in fertile women was lower than in nonpregnant women, who had never been pregnant previously.
作者简介
V. Mikhailova
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
编辑信件的主要联系方式.
Email: mva_spb@mail.ru
俄罗斯联邦, St. Petersburg
D. Bazhenov
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: mva_spb@mail.ru
俄罗斯联邦, St. Petersburg
L. Viazmina
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: mva_spb@mail.ru
俄罗斯联邦, St. Petersburg
A. Agnaeva
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: mva_spb@mail.ru
俄罗斯联邦, St. Petersburg
O. Bespalova
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: mva_spb@mail.ru
俄罗斯联邦, St. Petersburg
S. Sel’kov
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: mva_spb@mail.ru
俄罗斯联邦, St. Petersburg
D. Sokolov
D. O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: mva_spb@mail.ru
俄罗斯联邦, St. Petersburg
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