Analgesic Activity of Hexaazaisowurtzitane Derivatives
- 作者: Krylova S.1, Povet’eva T.1, Zueva E.1, Suslov N.1, Amosova E.1, Razina T.1, Lopatina K.1, Rybalkina O.1, Nesterova Y.1, Afanas’eva O.1, Kiseleva E.1, Sysolyatin S.2, Kulagina D.2, Zhdanov V.1
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隶属关系:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
- Institute of Problems of Chemical and Energetic Technologies, Siberian Division of the Russian Academy of Sciences
- 期: 卷 166, 编号 4 (2019)
- 页面: 461-465
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241104
- DOI: https://doi.org/10.1007/s10517-019-04372-9
- ID: 241104
如何引用文章
详细
Pronounced analgesic activity of the innovative compound 4-(3,4-dibromthiophencarbonyl)-2,6,8,12-tetraacethyl-2,4,6,8,10,12hexaazatetracyclo[5,5,0,03, 11,05, 9] dodecane (thiowurtzine) was observed in the thermal nociceptive hot plate test and in the acute visceral and somatic deep pain model (acetic acid writhing test). In these experimental models, naloxone-sensitive thiowurtzine-induced analgesia was revealed. The absence of tropism to peripheral opioid receptors in the acetic acid writhing test was demonstrated using naloxone methiodide. Course administration of low-toxic thiowurtzine in effective doses was not associated with ulcerogenic damage to the gastric mucosa in experimental animals.
作者简介
S. Krylova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
编辑信件的主要联系方式.
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
T. Povet’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
E. Zueva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
N. Suslov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
E. Amosova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
T. Razina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
K. Lopatina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
O. Rybalkina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
Yu. Nesterova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
O. Afanas’eva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
E. Kiseleva
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
S. Sysolyatin
Institute of Problems of Chemical and Energetic Technologies, Siberian Division of the Russian Academy of Sciences
Email: krylova5935@gmail.com
俄罗斯联邦, Biysk
D. Kulagina
Institute of Problems of Chemical and Energetic Technologies, Siberian Division of the Russian Academy of Sciences
Email: krylova5935@gmail.com
俄罗斯联邦, Biysk
V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center
Email: krylova5935@gmail.com
俄罗斯联邦, Tomsk
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