Low Blood Content of IL-10-Producing CD4+ T Cells as a Risk Factor for Progression of Coronary Atherosclerosis
- 作者: Filatova A.1, Pylaeva E.1, Potekhina A.1, Ruleva N.1, Klesareva E.1, Radyukhina N.1, Masenko V.1, Shchinova A.1, Noeva E.1, Provatorov S.1, Afanas’eva O.1, Aref’eva T.1
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隶属关系:
- Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- 期: 卷 166, 编号 3 (2019)
- 页面: 330-333
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240999
- DOI: https://doi.org/10.1007/s10517-019-04344-z
- ID: 240999
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详细
In a 2-year prospective study, prognostic significance of the blood content of IL-10-producing CD4+ T lymphocytes for progression of coronary artery atherosclerosis was assessed. Patients with verified stable angina (n=36) admitted for scheduled coronary angiography and coronary stenting were enrolled. The blood levels of CD4+FoxpP3+ Treg, CD4+IFNγ+ Th1, CD4+IL17+ Th17, CD4+IL10+ cells, sCD25, IL-10, IL-17, C-reactive protein, and lipoprotein (a) were assayed before endovascular interventions. The blood content of CD4+IL10+ T cells below 3.3% was associated with progression of coronary artery atherosclerosis (OR 12.0 (2.3, 61.0), sensitivity 77%, specificity 78%, p=0.003). No differences in other immunological parameters and common atherosclerosis risk factors in the groups were revealed. We hypothesize that the content of CD4+IL10+ T cells can be an important predictive marker for the progression of coronary atherosclerosis.
作者简介
A. Filatova
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
E. Pylaeva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
A. Potekhina
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
N. Ruleva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
E. Klesareva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
N. Radyukhina
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
V. Masenko
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
A. Shchinova
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
E. Noeva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
S. Provatorov
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
O. Afanas’eva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
T. Aref’eva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
俄罗斯联邦, Moscow
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