Low Blood Content of IL-10-Producing CD4+ T Cells as a Risk Factor for Progression of Coronary Atherosclerosis
- Autores: Filatova A.1, Pylaeva E.1, Potekhina A.1, Ruleva N.1, Klesareva E.1, Radyukhina N.1, Masenko V.1, Shchinova A.1, Noeva E.1, Provatorov S.1, Afanas’eva O.1, Aref’eva T.1
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Afiliações:
- Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
- Edição: Volume 166, Nº 3 (2019)
- Páginas: 330-333
- Seção: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240999
- DOI: https://doi.org/10.1007/s10517-019-04344-z
- ID: 240999
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Resumo
In a 2-year prospective study, prognostic significance of the blood content of IL-10-producing CD4+ T lymphocytes for progression of coronary artery atherosclerosis was assessed. Patients with verified stable angina (n=36) admitted for scheduled coronary angiography and coronary stenting were enrolled. The blood levels of CD4+FoxpP3+ Treg, CD4+IFNγ+ Th1, CD4+IL17+ Th17, CD4+IL10+ cells, sCD25, IL-10, IL-17, C-reactive protein, and lipoprotein (a) were assayed before endovascular interventions. The blood content of CD4+IL10+ T cells below 3.3% was associated with progression of coronary artery atherosclerosis (OR 12.0 (2.3, 61.0), sensitivity 77%, specificity 78%, p=0.003). No differences in other immunological parameters and common atherosclerosis risk factors in the groups were revealed. We hypothesize that the content of CD4+IL10+ T cells can be an important predictive marker for the progression of coronary atherosclerosis.
Sobre autores
A. Filatova
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: anastasia.m088@yandex.ru
Rússia, Moscow
E. Pylaeva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
A. Potekhina
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
N. Ruleva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
E. Klesareva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
N. Radyukhina
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
V. Masenko
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
A. Shchinova
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
E. Noeva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
S. Provatorov
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
O. Afanas’eva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
T. Aref’eva
Federal Medical Research Center of Cardiology, Ministry of Health of the Russian Federation
Email: anastasia.m088@yandex.ru
Rússia, Moscow
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