Effect of Activation of Peripheral Ion Channel TRPM8 on Gene Expression of Thermosensitive TRP Ion Channels in the Hypothalamus. Comparison with the Effect of Cooling
- 作者: Kozyreva T.1, Evtushenko A.1, Voronova I.1, Khramova G.1, Kozaruk V.1
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隶属关系:
- Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences Novosibirsk
- 期: 卷 166, 编号 2 (2018)
- 页面: 188-191
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240901
- DOI: https://doi.org/10.1007/s10517-018-4311-7
- ID: 240901
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详细
Experiments on rats showed that activation of the peripheral ion channel TRPM8 with menthol and rapid cooling (decrease in core temperature by 3°C) led to 1.5-fold activation of the expression of TRPV3 ion channel gene in the posterior hypothalamus, but had no effect on the expression of this gene in the anterior hypothalamus. Neither stimulation of peripheral TRPМ8, nor acute cooling affected the expression of genes for other thermosensitive ion channels (TRPV1, TRPV2, TRPV4, TRPA1, and TRPМ8) in the hypothalamus. Enhanced expression of Trpv3 gene can indicate increased sensitivity of hypothalamic neurons in the range of TRPV3 ion channel functioning (31-39oC). The relationship between the changes in Trpv3 gene expression and the shift of thermoregulatory reaction thresholds is discussed. Our findings attest to the presence of a functional relationship between TRP ion channels of the peripheral nervous system and TRP channels in the central structures of the brain.
作者简介
T. Kozyreva
Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences Novosibirsk
编辑信件的主要联系方式.
Email: kozyreva@physiol.ru
俄罗斯联邦, Siberia
A. Evtushenko
Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences Novosibirsk
Email: kozyreva@physiol.ru
俄罗斯联邦, Siberia
I. Voronova
Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences Novosibirsk
Email: kozyreva@physiol.ru
俄罗斯联邦, Siberia
G. Khramova
Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences Novosibirsk
Email: kozyreva@physiol.ru
俄罗斯联邦, Siberia
V. Kozaruk
Laboratory of Thermophysiology, Research Institute of Physiology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences Novosibirsk
Email: kozyreva@physiol.ru
俄罗斯联邦, Siberia
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