Dysfunction of Neuromuscular Synapses in the Genetic Model of Alzheimer’s Disease
- 作者: Mukhamedyarov M.1, Grigor’ev P.1, Ushanova E.1,2, Zefirov T.2, Leushina A.1, Zefirov A.1
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隶属关系:
- Kazan State Medical University
- Kazan (Volga Region) Federal University
- 期: 卷 165, 编号 5 (2018)
- 页面: 669-673
- 栏目: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/240652
- DOI: https://doi.org/10.1007/s10517-018-4238-z
- ID: 240652
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详细
The function of synaptic transmission and presynaptic vesicular cycle in the neuromuscular synapses of the diaphragm was studied in transgenic APP/PS1 mice (Alzheimer’s disease model). The decrease in the quantal content of end-plate potential, intense depression of the amplitude of terminal plate potentials under conditions of lasting high frequency stimulation (50 Hz), a drastic prolongation of the synaptic vesicle recycling time in APP/PS1 mice in comparison with wild type mice were detected. Manifest dysfunction of the neuromuscular synapses, caused by disordered neurosecretion and recycling of the synaptic vesicles in the presynaptic nerve endings, was detected in the Alzheimer’s disease model on transgenic APP/PS1 mice. The study supplemented the notions on the pathogenesis of Alzheimer’s disease as a systemic disease, while the detected phenomena could just partially explain the development of motor disorders in this disease.
作者简介
M. Mukhamedyarov
Kazan State Medical University
编辑信件的主要联系方式.
Email: maratm80@list.ru
俄罗斯联邦, Kazan
P. Grigor’ev
Kazan State Medical University
Email: maratm80@list.ru
俄罗斯联邦, Kazan
E. Ushanova
Kazan State Medical University; Kazan (Volga Region) Federal University
Email: maratm80@list.ru
俄罗斯联邦, Kazan; Kazan, Tatarstan Republic
T. Zefirov
Kazan (Volga Region) Federal University
Email: maratm80@list.ru
俄罗斯联邦, Kazan, Tatarstan Republic
A. Leushina
Kazan State Medical University
Email: maratm80@list.ru
俄罗斯联邦, Kazan
A. Zefirov
Kazan State Medical University
Email: maratm80@list.ru
俄罗斯联邦, Kazan