Dysfunction of Neuromuscular Synapses in the Genetic Model of Alzheimer’s Disease
- Autores: Mukhamedyarov M.1, Grigor’ev P.1, Ushanova E.1,2, Zefirov T.2, Leushina A.1, Zefirov A.1
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Afiliações:
- Kazan State Medical University
- Kazan (Volga Region) Federal University
- Edição: Volume 165, Nº 5 (2018)
- Páginas: 669-673
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/240652
- DOI: https://doi.org/10.1007/s10517-018-4238-z
- ID: 240652
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Resumo
The function of synaptic transmission and presynaptic vesicular cycle in the neuromuscular synapses of the diaphragm was studied in transgenic APP/PS1 mice (Alzheimer’s disease model). The decrease in the quantal content of end-plate potential, intense depression of the amplitude of terminal plate potentials under conditions of lasting high frequency stimulation (50 Hz), a drastic prolongation of the synaptic vesicle recycling time in APP/PS1 mice in comparison with wild type mice were detected. Manifest dysfunction of the neuromuscular synapses, caused by disordered neurosecretion and recycling of the synaptic vesicles in the presynaptic nerve endings, was detected in the Alzheimer’s disease model on transgenic APP/PS1 mice. The study supplemented the notions on the pathogenesis of Alzheimer’s disease as a systemic disease, while the detected phenomena could just partially explain the development of motor disorders in this disease.
Sobre autores
M. Mukhamedyarov
Kazan State Medical University
Autor responsável pela correspondência
Email: maratm80@list.ru
Rússia, Kazan
P. Grigor’ev
Kazan State Medical University
Email: maratm80@list.ru
Rússia, Kazan
E. Ushanova
Kazan State Medical University; Kazan (Volga Region) Federal University
Email: maratm80@list.ru
Rússia, Kazan; Kazan, Tatarstan Republic
T. Zefirov
Kazan (Volga Region) Federal University
Email: maratm80@list.ru
Rússia, Kazan, Tatarstan Republic
A. Leushina
Kazan State Medical University
Email: maratm80@list.ru
Rússia, Kazan
A. Zefirov
Kazan State Medical University
Email: maratm80@list.ru
Rússia, Kazan