Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger in Alcoholic Cardiomyopathy
- 作者: Kozhevnikova L.1, Tsorin I.2, Stolyaruk V.2, Sukhanova I.1, Vititnova M.2, Nikiforova T.2, Kolik L.2, Kryzhanovskii S.2
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隶属关系:
- Research Institute of General Pathology and Pathophysiology
- V. V. Za-kusov Research Institute of Pharmacology
- 期: 卷 165, 编号 5 (2018)
- 页面: 613-616
- 栏目: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240600
- DOI: https://doi.org/10.1007/s10517-018-4225-4
- ID: 240600
如何引用文章
详细
The expression of Epac proteins (exchange protein directly activated by cAMP) and calmodulin (CaM) was assessed by the content of the corresponding mRNA in biopsy specimens of cardiac atrium, left ventricle, and thoracic aorta of rats with alcoholic cardiomyopathy. In the myocardium, overexpression of Еpac1, Ерас2, and СаМ mRNA was found. The content of Epac2 mRNA in the left ventricle was elevated by 2.9 times (p=0.000001), in the left atrium by 3.2 times (p=0.00001), in the right atrium by 3 times (p=0.00001). In contrast to the myocardial tissue, the content of CaM mRNA in the thoracic aorta was not increased, but showed a tendency to decrease, when compared to the control values, while the level of Epac1 and Epac2 mRNA was increased. The assumption is made that regulatory proteins Epac and CaM can play a key role in arrhythmogenesis development under conditions of alcoholic cardiomyopathy.
作者简介
L. Kozhevnikova
Research Institute of General Pathology and Pathophysiology
Email: SAK-538@yandex.ru
俄罗斯联邦, Moscow
I. Tsorin
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
俄罗斯联邦, Moscow
V. Stolyaruk
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
俄罗斯联邦, Moscow
I. Sukhanova
Research Institute of General Pathology and Pathophysiology
Email: SAK-538@yandex.ru
俄罗斯联邦, Moscow
M. Vititnova
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
俄罗斯联邦, Moscow
T. Nikiforova
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
俄罗斯联邦, Moscow
L. Kolik
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
俄罗斯联邦, Moscow
S. Kryzhanovskii
V. V. Za-kusov Research Institute of Pharmacology
编辑信件的主要联系方式.
Email: SAK-538@yandex.ru
俄罗斯联邦, Moscow