Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger in Alcoholic Cardiomyopathy
- Autores: Kozhevnikova L.1, Tsorin I.2, Stolyaruk V.2, Sukhanova I.1, Vititnova M.2, Nikiforova T.2, Kolik L.2, Kryzhanovskii S.2
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Afiliações:
- Research Institute of General Pathology and Pathophysiology
- V. V. Za-kusov Research Institute of Pharmacology
- Edição: Volume 165, Nº 5 (2018)
- Páginas: 613-616
- Seção: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/240600
- DOI: https://doi.org/10.1007/s10517-018-4225-4
- ID: 240600
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Resumo
The expression of Epac proteins (exchange protein directly activated by cAMP) and calmodulin (CaM) was assessed by the content of the corresponding mRNA in biopsy specimens of cardiac atrium, left ventricle, and thoracic aorta of rats with alcoholic cardiomyopathy. In the myocardium, overexpression of Еpac1, Ерас2, and СаМ mRNA was found. The content of Epac2 mRNA in the left ventricle was elevated by 2.9 times (p=0.000001), in the left atrium by 3.2 times (p=0.00001), in the right atrium by 3 times (p=0.00001). In contrast to the myocardial tissue, the content of CaM mRNA in the thoracic aorta was not increased, but showed a tendency to decrease, when compared to the control values, while the level of Epac1 and Epac2 mRNA was increased. The assumption is made that regulatory proteins Epac and CaM can play a key role in arrhythmogenesis development under conditions of alcoholic cardiomyopathy.
Sobre autores
L. Kozhevnikova
Research Institute of General Pathology and Pathophysiology
Email: SAK-538@yandex.ru
Rússia, Moscow
I. Tsorin
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Rússia, Moscow
V. Stolyaruk
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Rússia, Moscow
I. Sukhanova
Research Institute of General Pathology and Pathophysiology
Email: SAK-538@yandex.ru
Rússia, Moscow
M. Vititnova
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Rússia, Moscow
T. Nikiforova
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Rússia, Moscow
L. Kolik
V. V. Za-kusov Research Institute of Pharmacology
Email: SAK-538@yandex.ru
Rússia, Moscow
S. Kryzhanovskii
V. V. Za-kusov Research Institute of Pharmacology
Autor responsável pela correspondência
Email: SAK-538@yandex.ru
Rússia, Moscow