Transforming Growth Factor-β and Tumor Necrosis Factor-α Reduce the Sensitivity of MiaPaCa2 Pancreatic Cancer Cells to Lysis by NK Cells
- 作者: Ostapchuk E.1, Kali A.1, Belyaev N.1
-
隶属关系:
- Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry
- 期: 卷 165, 编号 2 (2018)
- 页面: 259-263
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240211
- DOI: https://doi.org/10.1007/s10517-018-4143-5
- ID: 240211
如何引用文章
详细
We studied the role of cytokines TGF-β and TNFα in reduction of the cytolytic activity of NK cells towards tumor cells. Exogenous TGF-β and TNFα reduced the sensitivity of MiaPaCa2 pancreatic adenocarcinoma cells to NK cytotoxicity, which was associated with reduction of ULBP-1 expression and increase of HLA-E, HLA-G, CD155, and CD112 expression on Mia-PaCa2 cells. Changes in the expression of ligands for NK receptors on tumor cells induced by TGF-β and TNFα may contribute to reduction of cytotoxicity of tumor-associated NK cells and thus prevent an adequate antitumor immune response leading to the disease progress.
作者简介
E. Ostapchuk
Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry
编辑信件的主要联系方式.
Email: katyostapchuk@gmail.com
哈萨克斯坦, Almaty
A. Kali
Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry
Email: katyostapchuk@gmail.com
哈萨克斯坦, Almaty
N. Belyaev
Laboratory of Molecular Immunology and Immunobiotechnology, M. A. Aitkhodzhin Institute of Molecular Biology and Biochemistry
Email: katyostapchuk@gmail.com
哈萨克斯坦, Almaty