Hormonal Regulation of Dendritic Cell Differentiation in the Thymus


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详细

We studied the effect of hormones estriol, ghrelin, kisspeptin, and chorionic gonadotropin in concentrations corresponding to their content in the peripheral blood in each trimester of pregnancy on the expression of membrane molecules on myeloid and plasmacytoid dendritic cells of the thymus. It was found that thymic myeloid dendritic cells are sensitive to the action of estriol and kisspeptin. Estriol in a concentration of the first trimester of pregnancy reduces the number of myeloid dendritic cells expressing receptor for thymic stromal lymphopoietin (CD11c+TSLP-R+) and inhibitory molecule B7-H3 (CD11c+CD276+). In contrast to estriol, kisspeptin regulates the processes of differentiation of thymic myeloid dendritic cells in concentrations typical of the second-third trimesters and reduced their total number (CD11c+) and the number of cells expressing TSLP-R (CD11c+TSLP-R+). Estriol and kisspeptin do not affect the total number of plasmacytoid dendritic cells (CD303+) and expression of TSLP-R and CD276 by these cells. Ghrelin and chorionic gonadotropin in the studied concentrations had no significant effect on the total number of thymic myeloid and plasmacytoid dendritic cells and on the expression of membrane molecules of TSLP-R and CD276.

作者简介

S. Shirshev

Laboratory of Immunoregulation, Perm Federal Research Center of the Institute of Ecology and Genetics of Microorganisms, the Ural Division of the Russian Academy of Sciences

Email: orlova_katy@mail.ru
俄罗斯联邦, Perm

E. Orlova

Laboratory of Immunoregulation, Perm Federal Research Center of the Institute of Ecology and Genetics of Microorganisms, the Ural Division of the Russian Academy of Sciences

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Email: orlova_katy@mail.ru
俄罗斯联邦, Perm

O. Loginova

Laboratory of Immunoregulation, Perm Federal Research Center of the Institute of Ecology and Genetics of Microorganisms, the Ural Division of the Russian Academy of Sciences

Email: orlova_katy@mail.ru
俄罗斯联邦, Perm

I. Nekrasova

Laboratory of Immunoregulation, Perm Federal Research Center of the Institute of Ecology and Genetics of Microorganisms, the Ural Division of the Russian Academy of Sciences

Email: orlova_katy@mail.ru
俄罗斯联邦, Perm

O. Gorbunova

Laboratory of Immunoregulation, Perm Federal Research Center of the Institute of Ecology and Genetics of Microorganisms, the Ural Division of the Russian Academy of Sciences

Email: orlova_katy@mail.ru
俄罗斯联邦, Perm

I. Maslennikova

Laboratory of Immunoregulation, Perm Federal Research Center of the Institute of Ecology and Genetics of Microorganisms, the Ural Division of the Russian Academy of Sciences

Email: orlova_katy@mail.ru
俄罗斯联邦, Perm


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