Role of Endogenous Melatonin in the Regulation of Th17/Treg Balance during Pregnancy
- 作者: Glebezdina N.1, Olina A.2, Nekrasova I.1, Kuklina E.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
- E. A. Wagner Perm State Medical University
- 期: 卷 164, 编号 4 (2018)
- 页面: 462-465
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239687
- DOI: https://doi.org/10.1007/s10517-018-4013-1
- ID: 239687
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详细
We studied the role of endogenous melatonin in the development and functioning of T cells that produce IL-17 (Th17) and regulatory T cells (Treg) during pregnancy. The study was performed ex vivo and in vitro with auto-serum as the source of endogenous melatonin under conditions of blockade of melatonin-dependent signaling. Participation of the hormone in the regulation of differentiation of both CD4+RORγt+ and CD4+FoxP3+T cells and their key products IL-17A and TGF-β was demonstrated. It is known that the normal gestational process is accompanied by a decrease in Th17/Treg ratio due to hormonal changes. The sensitivity of the studied subpopulations to melatonin during pregnancy can affect its outcome.
作者简介
N. Glebezdina
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: glebezdina_n@mail.ru
俄罗斯联邦, Perm
A. Olina
E. A. Wagner Perm State Medical University
Email: glebezdina_n@mail.ru
俄罗斯联邦, Perm
I. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: glebezdina_n@mail.ru
俄罗斯联邦, Perm
E. Kuklina
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: glebezdina_n@mail.ru
俄罗斯联邦, Perm