Role of Endogenous Melatonin in the Regulation of Th17/Treg Balance during Pregnancy
- Authors: Glebezdina N.S.1, Olina A.A.2, Nekrasova I.V.1, Kuklina E.M.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
- E. A. Wagner Perm State Medical University
- Issue: Vol 164, No 4 (2018)
- Pages: 462-465
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239687
- DOI: https://doi.org/10.1007/s10517-018-4013-1
- ID: 239687
Cite item
Abstract
We studied the role of endogenous melatonin in the development and functioning of T cells that produce IL-17 (Th17) and regulatory T cells (Treg) during pregnancy. The study was performed ex vivo and in vitro with auto-serum as the source of endogenous melatonin under conditions of blockade of melatonin-dependent signaling. Participation of the hormone in the regulation of differentiation of both CD4+RORγt+ and CD4+FoxP3+T cells and their key products IL-17A and TGF-β was demonstrated. It is known that the normal gestational process is accompanied by a decrease in Th17/Treg ratio due to hormonal changes. The sensitivity of the studied subpopulations to melatonin during pregnancy can affect its outcome.
About the authors
N. S. Glebezdina
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: glebezdina_n@mail.ru
Russian Federation, Perm
A. A. Olina
E. A. Wagner Perm State Medical University
Email: glebezdina_n@mail.ru
Russian Federation, Perm
I. V. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: glebezdina_n@mail.ru
Russian Federation, Perm
E. M. Kuklina
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: glebezdina_n@mail.ru
Russian Federation, Perm