Algorithm of Molecular and Biological Assessment of the Mechanisms of Sensitivity to Drug Toxicity by the Example of Cyclophosphamide
- 作者: Telegin L.1, Sarmanaev S.2, Devichenskii V.2, Tutelyan V.3
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隶属关系:
- Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences
- Institute for Advanced Studies, Federal Medical-Biological Agency
- Federal Research Centre of Nutrition, Biotechnology and Food Safety
- 期: 卷 164, 编号 3 (2018)
- 页面: 324-329
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239578
- DOI: https://doi.org/10.1007/s10517-018-3982-4
- ID: 239578
如何引用文章
详细
Comparative study of the liver, blood, and spleen of DBA/2JSto and BALB/cJLacSto mice sensitive and resistant to acute toxicity of the cyclophosphamide allowed us to reveal basic toxicity biomarkers of this antitumor and immunosuppressive agent. Obtained results can be used for the development of an algorithm for evaluation of toxic effects of drugs and food components.
作者简介
L. Telegin
Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: tell2003@post.ru
俄罗斯联邦, Moscow
S. Sarmanaev
Institute for Advanced Studies, Federal Medical-Biological Agency
Email: tell2003@post.ru
俄罗斯联邦, Moscow
V. Devichenskii
Institute for Advanced Studies, Federal Medical-Biological Agency
Email: tell2003@post.ru
俄罗斯联邦, Moscow
V. Tutelyan
Federal Research Centre of Nutrition, Biotechnology and Food Safety
Email: tell2003@post.ru
俄罗斯联邦, Moscow