Algorithm of Molecular and Biological Assessment of the Mechanisms of Sensitivity to Drug Toxicity by the Example of Cyclophosphamide


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详细

Comparative study of the liver, blood, and spleen of DBA/2JSto and BALB/cJLacSto mice sensitive and resistant to acute toxicity of the cyclophosphamide allowed us to reveal basic toxicity biomarkers of this antitumor and immunosuppressive agent. Obtained results can be used for the development of an algorithm for evaluation of toxic effects of drugs and food components.

作者简介

L. Telegin

Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences

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Email: tell2003@post.ru
俄罗斯联邦, Moscow

S. Sarmanaev

Institute for Advanced Studies, Federal Medical-Biological Agency

Email: tell2003@post.ru
俄罗斯联邦, Moscow

V. Devichenskii

Institute for Advanced Studies, Federal Medical-Biological Agency

Email: tell2003@post.ru
俄罗斯联邦, Moscow

V. Tutelyan

Federal Research Centre of Nutrition, Biotechnology and Food Safety

Email: tell2003@post.ru
俄罗斯联邦, Moscow


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