Effects of Bone Marrow Multipotent Mesenchymal Stromal Cells and Their Secretion Products on the Cellular Composition of the Thymus and Spleen of Female Wistar Rats with Experimental Chronic Inflammation of the Internal Genitals
- 作者: Dergacheva T.1, Shurlygina A.1,2, Mel’nikova E.2, Gritsyk O.2, Tenditnik M.2, Poveshchenko O.1, Konenkov V.1
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隶属关系:
- Research Institute of Clinical and Experimental Lymphology
- Research Institute of Physiology and Basic Medicine
- 期: 卷 164, 编号 1 (2017)
- 页面: 75-79
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239369
- DOI: https://doi.org/10.1007/s10517-017-3928-2
- ID: 239369
如何引用文章
详细
The effects of bone marrow multipotent mesenchymal stromal cells and their secretion products on the subpopulation composition of thymic and splenic lymphocytes were studied in female Wistar rats with experimental chronic inflammatory process in the internal genitals. Stromal cells and medium conditioned by these cells in different administration routes (intravenous or lymphotropic injection) produces different modulating effect on blood leukocyte count and on subpopulation composition of the splenic and thymic lymphocytes. The most manifest anti-inflammatory effect was observed after lymphotropic injection of multipotent mesenchymal stromal cells creating a high concentration and long persistence of the factors produced by these cells in the focus of inflammation.
作者简介
T. Dergacheva
Research Institute of Clinical and Experimental Lymphology
编辑信件的主要联系方式.
Email: dr-tanja@yandex.ru
俄罗斯联邦, Novosibirsk
A. Shurlygina
Research Institute of Clinical and Experimental Lymphology; Research Institute of Physiology and Basic Medicine
Email: dr-tanja@yandex.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
E. Mel’nikova
Research Institute of Physiology and Basic Medicine
Email: dr-tanja@yandex.ru
俄罗斯联邦, Novosibirsk
O. Gritsyk
Research Institute of Physiology and Basic Medicine
Email: dr-tanja@yandex.ru
俄罗斯联邦, Novosibirsk
M. Tenditnik
Research Institute of Physiology and Basic Medicine
Email: dr-tanja@yandex.ru
俄罗斯联邦, Novosibirsk
O. Poveshchenko
Research Institute of Clinical and Experimental Lymphology
Email: dr-tanja@yandex.ru
俄罗斯联邦, Novosibirsk
V. Konenkov
Research Institute of Clinical and Experimental Lymphology
Email: dr-tanja@yandex.ru
俄罗斯联邦, Novosibirsk