Effects of Bone Marrow Multipotent Mesenchymal Stromal Cells and Their Secretion Products on the Cellular Composition of the Thymus and Spleen of Female Wistar Rats with Experimental Chronic Inflammation of the Internal Genitals
- Authors: Dergacheva T.I.1, Shurlygina A.V.1,2, Mel’nikova E.V.2, Gritsyk O.B.2, Tenditnik M.V.2, Poveshchenko O.V.1, Konenkov V.I.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology
- Research Institute of Physiology and Basic Medicine
- Issue: Vol 164, No 1 (2017)
- Pages: 75-79
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239369
- DOI: https://doi.org/10.1007/s10517-017-3928-2
- ID: 239369
Cite item
Abstract
The effects of bone marrow multipotent mesenchymal stromal cells and their secretion products on the subpopulation composition of thymic and splenic lymphocytes were studied in female Wistar rats with experimental chronic inflammatory process in the internal genitals. Stromal cells and medium conditioned by these cells in different administration routes (intravenous or lymphotropic injection) produces different modulating effect on blood leukocyte count and on subpopulation composition of the splenic and thymic lymphocytes. The most manifest anti-inflammatory effect was observed after lymphotropic injection of multipotent mesenchymal stromal cells creating a high concentration and long persistence of the factors produced by these cells in the focus of inflammation.
About the authors
T. I. Dergacheva
Research Institute of Clinical and Experimental Lymphology
Author for correspondence.
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
A. V. Shurlygina
Research Institute of Clinical and Experimental Lymphology; Research Institute of Physiology and Basic Medicine
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk; Novosibirsk
E. V. Mel’nikova
Research Institute of Physiology and Basic Medicine
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
O. B. Gritsyk
Research Institute of Physiology and Basic Medicine
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
M. V. Tenditnik
Research Institute of Physiology and Basic Medicine
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
O. V. Poveshchenko
Research Institute of Clinical and Experimental Lymphology
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology
Email: dr-tanja@yandex.ru
Russian Federation, Novosibirsk