Possibility of Aggravation of Tissue Sclerosis after Injection of Multipotent Mesenchymal Stromal Cells Near the Forming Cicatrix in the Experiment
- 作者: Maiborodin I.1, Morozov V.1, Anikeev A.1, Figurenko N.1, Maslov R.1, Matveeva V.1, Chastikina G.1, Maiborodina V.2
-
隶属关系:
- Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Laboratory of Ultrastructural Bases of Pathology, Institute of Molecular Pathology and Pathomorphology
- 期: 卷 163, 编号 4 (2017)
- 页面: 554-560
- 栏目: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239085
- DOI: https://doi.org/10.1007/s10517-017-3848-1
- ID: 239085
如何引用文章
详细
The peculiarities of tissue sclerosis after injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and stained with Vybrant CM-Dil cell membrane dye were studied by light microscopy with luminescence. The surgical intervention consisting in ligation of the great vein was followed by tissue sclerotic transformation caused by direct damage and chronic inflammation caused by the presence of slowly resorbed ligature. Injection of stromal cells after this intervention led to formation of more extensive scar. This can attest to the possibility of stromal cells differentiation into connective tissue cells, fibroblasts, and stimulation of proliferation and collagen synthesis by host fibroblasts. A decrease in the volume of dense fibrous connective tissue due to scar reorganization at latter terms cannot not excluded.
作者简介
I. Maiborodin
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
V. Morozov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
A. Anikeev
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
N. Figurenko
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
R. Maslov
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
V. Matveeva
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
G. Chastikina
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk
V. Maiborodina
Laboratory of Ultrastructural Bases of Pathology, Institute of Molecular Pathology and Pathomorphology
Email: imai@mail.ru
俄罗斯联邦, Novosibirsk