Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide
- 作者: Khusnutdinov R.1, Boichuk S.1
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隶属关系:
- Kazan State Medical University
- 期: 卷 163, 编号 2 (2017)
- 页面: 260-262
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238801
- DOI: https://doi.org/10.1007/s10517-017-3779-x
- ID: 238801
如何引用文章
详细
We studied the mechanisms of sensitivity of soft tissue sarcoma cells to alkylating agent temozolomide. The mechanisms of tumor cell sensitivity to temozolomide are complex and are determined by not only the level of O6-methylguanine-DNA-methyltransferase (MGTM) expression, but also activity of oncosuppressor protein p53. A-673 Ewing’s sarcoma cells were found to be the most sensitive to temozolomide, whereas temozolomide-treated SK-LMS-1 leiomyosarcoma cells exhibited signs of cell aging.
作者简介
R. Khusnutdinov
Kazan State Medical University
Email: boichuksergei@mail.ru
俄罗斯联邦, Kazan, Republic of Tatarstan
S. Boichuk
Kazan State Medical University
编辑信件的主要联系方式.
Email: boichuksergei@mail.ru
俄罗斯联邦, Kazan, Republic of Tatarstan