Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide
- Авторы: Khusnutdinov R.1, Boichuk S.1
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Учреждения:
- Kazan State Medical University
- Выпуск: Том 163, № 2 (2017)
- Страницы: 260-262
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238801
- DOI: https://doi.org/10.1007/s10517-017-3779-x
- ID: 238801
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Аннотация
We studied the mechanisms of sensitivity of soft tissue sarcoma cells to alkylating agent temozolomide. The mechanisms of tumor cell sensitivity to temozolomide are complex and are determined by not only the level of O6-methylguanine-DNA-methyltransferase (MGTM) expression, but also activity of oncosuppressor protein p53. A-673 Ewing’s sarcoma cells were found to be the most sensitive to temozolomide, whereas temozolomide-treated SK-LMS-1 leiomyosarcoma cells exhibited signs of cell aging.
Об авторах
R. Khusnutdinov
Kazan State Medical University
Email: boichuksergei@mail.ru
Россия, Kazan, Republic of Tatarstan
S. Boichuk
Kazan State Medical University
Автор, ответственный за переписку.
Email: boichuksergei@mail.ru
Россия, Kazan, Republic of Tatarstan