Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome
- 作者: Derkach K.1, Ivantsov A.1, Chistyakova O.1, Sukhov I.1, Buzanakov D.1, Kulikova A.1, Shpakov A.1
-
隶属关系:
- Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
- 期: 卷 163, 编号 2 (2017)
- 页面: 184-189
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238742
- DOI: https://doi.org/10.1007/s10517-017-3762-6
- ID: 238742
如何引用文章
详细
We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of pancreatic β cells, and insulin system in the liver of rats with cafeteria diet-induced metabolic syndrome. The therapy reduced body weight and blood levels of insulin, triglycerides, and atherogenic cholesterol that are typically increased in metabolic syndrome, normalized glucose tolerance and its utilization, and increased activity of insulin signaling system in the liver, thus reducing insulin resistance. The therapy did not affect the number of pancreatic islets and β cells. The study demonstrates prospects of using intranasal insulin for correction of metabolic parameters and reduction of insulin resistance in metabolic syndrome.
作者简介
K. Derkach
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
俄罗斯联邦, St. Petersburg
A. Ivantsov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
俄罗斯联邦, St. Petersburg
O. Chistyakova
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
俄罗斯联邦, St. Petersburg
I. Sukhov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
俄罗斯联邦, St. Petersburg
D. Buzanakov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
俄罗斯联邦, St. Petersburg
A. Kulikova
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
俄罗斯联邦, St. Petersburg
A. Shpakov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: alex_shpakov@list.ru
俄罗斯联邦, St. Petersburg