Intranasal Insulin Restores Metabolic Parameters and Insulin Sensitivity in Rats with Metabolic Syndrome
- Authors: Derkach K.V.1, Ivantsov A.O.1, Chistyakova O.V.1, Sukhov I.B.1, Buzanakov D.M.1, Kulikova A.A.1, Shpakov A.O.1
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Affiliations:
- Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
- Issue: Vol 163, No 2 (2017)
- Pages: 184-189
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238742
- DOI: https://doi.org/10.1007/s10517-017-3762-6
- ID: 238742
Cite item
Abstract
We studied the effect of 10-week treatment with intranasal insulin (0.5 IU/day) on glucose tolerance, glucose utilization, lipid metabolism, functions of pancreatic β cells, and insulin system in the liver of rats with cafeteria diet-induced metabolic syndrome. The therapy reduced body weight and blood levels of insulin, triglycerides, and atherogenic cholesterol that are typically increased in metabolic syndrome, normalized glucose tolerance and its utilization, and increased activity of insulin signaling system in the liver, thus reducing insulin resistance. The therapy did not affect the number of pancreatic islets and β cells. The study demonstrates prospects of using intranasal insulin for correction of metabolic parameters and reduction of insulin resistance in metabolic syndrome.
About the authors
K. V. Derkach
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
A. O. Ivantsov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
O. V. Chistyakova
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
I. B. Sukhov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
D. M. Buzanakov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
A. A. Kulikova
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg
A. O. Shpakov
Laboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences
Author for correspondence.
Email: alex_shpakov@list.ru
Russian Federation, St. Petersburg