Delayed Results of Experimental Afobazole Therapy in Rats after Acute Myocardial Infarction
- 作者: Kryzhanovskii S.1, Tsorin I.1, Stolyaruk V.1, Ionova E.1, Vititnova M.1
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隶属关系:
- V. V. Zakusov Research Institute of Pharmacology
- 期: 卷 163, 编号 2 (2017)
- 页面: 180-183
- 栏目: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238738
- DOI: https://doi.org/10.1007/s10517-017-3761-7
- ID: 238738
如何引用文章
详细
Delayed cardioprotective effects of anxiolytic Afobazole (15 mg/kg, intraperitoneally for 14 days) were evaluated using dynamic echocardiographic recordings on days 2, 15, 56, and 98 after experimental myocardial infarction modeling (rat model of acute myocardial ischemia). The cardiotropic activity of Afobazole is assumed to be related to its agonistic effects on σ1 receptor of cardiomyocytes. It was found that animals treated with Afobazole had no signs of heart failure by the end of observation, as evidenced by left ventricular ejection fraction.
作者简介
S. Kryzhanovskii
V. V. Zakusov Research Institute of Pharmacology
编辑信件的主要联系方式.
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
I. Tsorin
V. V. Zakusov Research Institute of Pharmacology
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
V. Stolyaruk
V. V. Zakusov Research Institute of Pharmacology
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
E. Ionova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
M. Vititnova
V. V. Zakusov Research Institute of Pharmacology
Email: SAK_538@yandex.ru
俄罗斯联邦, Moscow
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