Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress
- 作者: Ivanov A.1, Bobyntsev I.2, Shepeleva O.3, Kryukov A.2, Andreeva L.4, Myasoedov N.4
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隶属关系:
- Department of Histology, Embryology, and Cytology
- Department of Pathophysiology
- Department of General Hygiene, Kursk State Medical University
- Institute of Molecular Genetics, Russian Academy of Sciences
- 期: 卷 163, 编号 1 (2017)
- 页面: 105-108
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238685
- DOI: https://doi.org/10.1007/s10517-017-3748-4
- ID: 238685
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详细
We studied the effect of intraperitoneal administration of peptide ACTG4-7-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress. A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver and serum activity of ALT. The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration. The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein.
作者简介
A. Ivanov
Department of Histology, Embryology, and Cytology
Email: bobig@mail.ru
俄罗斯联邦, Kursk
I. Bobyntsev
Department of Pathophysiology
编辑信件的主要联系方式.
Email: bobig@mail.ru
俄罗斯联邦, Kursk
O. Shepeleva
Department of General Hygiene, Kursk State Medical University
Email: bobig@mail.ru
俄罗斯联邦, Kursk
A. Kryukov
Department of Pathophysiology
Email: bobig@mail.ru
俄罗斯联邦, Kursk
L. Andreeva
Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
俄罗斯联邦, Moscow
N. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
俄罗斯联邦, Moscow