Influence of ACTG4-7-PGP (Semax) on Morphofunctional State of Hepatocytes in Chronic Emotional and Painful Stress
- Авторы: Ivanov A.1, Bobyntsev I.2, Shepeleva O.3, Kryukov A.2, Andreeva L.4, Myasoedov N.4
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Учреждения:
- Department of Histology, Embryology, and Cytology
- Department of Pathophysiology
- Department of General Hygiene, Kursk State Medical University
- Institute of Molecular Genetics, Russian Academy of Sciences
- Выпуск: Том 163, № 1 (2017)
- Страницы: 105-108
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238685
- DOI: https://doi.org/10.1007/s10517-017-3748-4
- ID: 238685
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Аннотация
We studied the effect of intraperitoneal administration of peptide ACTG4-7-PGP to male Wistar rats in doses of 5, 50, 150, and 450 μg/kg on the morphofunctional state of hepatocytes in chronic emotional and painful stress. A dose-dependent stress-limiting effect of the peptide was observed: it normalized the protein synthesis function of the liver and serum activity of ALT. The anticytolytic effect of the peptide increased with increasing its dose against the background of the increase in the relative number of multinucleated and multinucleolated cells and deceleration of the recovery of serum protein concentration. The decrease of hepatocyte cytolysis against the background of more intense morphological signs of protein synthesis processes attests to activation of reparative processes in the liver parenchyma via enhanced constitutional synthesis of protein.
Об авторах
A. Ivanov
Department of Histology, Embryology, and Cytology
Email: bobig@mail.ru
Россия, Kursk
I. Bobyntsev
Department of Pathophysiology
Автор, ответственный за переписку.
Email: bobig@mail.ru
Россия, Kursk
O. Shepeleva
Department of General Hygiene, Kursk State Medical University
Email: bobig@mail.ru
Россия, Kursk
A. Kryukov
Department of Pathophysiology
Email: bobig@mail.ru
Россия, Kursk
L. Andreeva
Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
Россия, Moscow
N. Myasoedov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: bobig@mail.ru
Россия, Moscow
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