Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny
- 作者: Arutyunyan A.1, Zaloznyaya I.1, Kerkeshko G.1, Milyutina Y.1, Korenevskii A.1
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隶属关系:
- D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
- 期: 卷 162, 编号 6 (2017)
- 页面: 738-740
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238512
- DOI: https://doi.org/10.1007/s10517-017-3701-6
- ID: 238512
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详细
Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormone were revealed: the level of norepinephrine in the medial preoptic area decreased and concentration of dopamine in the median eminence with arcuate nuclei increased. Administration of melatonin attenuated the observed changes, which can be related to neuroprotective effects of this hormone determined by its antioxidant properties.
作者简介
A. Arutyunyan
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
编辑信件的主要联系方式.
Email: alexarutjunyan@gmail.com
俄罗斯联邦, St. Petersburg
I. Zaloznyaya
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: alexarutjunyan@gmail.com
俄罗斯联邦, St. Petersburg
G. Kerkeshko
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: alexarutjunyan@gmail.com
俄罗斯联邦, St. Petersburg
Yu. Milyutina
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: alexarutjunyan@gmail.com
俄罗斯联邦, St. Petersburg
A. Korenevskii
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: alexarutjunyan@gmail.com
俄罗斯联邦, St. Petersburg