Prenatal Hyperhomocysteinemia Impairs Hypothalamic Regulation of Reproductive Cycles in Rat Progeny
- Авторы: Arutyunyan A.1, Zaloznyaya I.1, Kerkeshko G.1, Milyutina Y.1, Korenevskii A.1
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Учреждения:
- D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
- Выпуск: Том 162, № 6 (2017)
- Страницы: 738-740
- Раздел: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238512
- DOI: https://doi.org/10.1007/s10517-017-3701-6
- ID: 238512
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Аннотация
Effects of prenatal hyperhomocysteinemia on hypothalamic regulation of estrous cycles were studied in female rats. In mature rats exposed to prenatal hyperhomocysteinemia, changes in the catecholamine content in hypothalamic areas responsible for the formation of the preovulatory surge of gonadotropin-releasing hormone were revealed: the level of norepinephrine in the medial preoptic area decreased and concentration of dopamine in the median eminence with arcuate nuclei increased. Administration of melatonin attenuated the observed changes, which can be related to neuroprotective effects of this hormone determined by its antioxidant properties.
Об авторах
A. Arutyunyan
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Автор, ответственный за переписку.
Email: alexarutjunyan@gmail.com
Россия, St. Petersburg
I. Zaloznyaya
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: alexarutjunyan@gmail.com
Россия, St. Petersburg
G. Kerkeshko
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: alexarutjunyan@gmail.com
Россия, St. Petersburg
Yu. Milyutina
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: alexarutjunyan@gmail.com
Россия, St. Petersburg
A. Korenevskii
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: alexarutjunyan@gmail.com
Россия, St. Petersburg