Role of Vascular Endothelial Growth Factor and Transforming Growth Factor-β2 in Rat Bone Tissue after Bone Fracture and Placement of Titanium Implants with Bioactive Bioresorbable Coatings
- 作者: Kalinichenko S.1,2, Matveeva N.1,2, Kostiv R.1, Puz’ A.2
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隶属关系:
- Department of Histology, Cytology, and Embryology, Pacific State Medical University
- Laboratory of Biomedical Composition Coatings, Institute of Chemistry, Far-East Division of Russian Academy of Sciences
- 期: 卷 162, 编号 5 (2017)
- 页面: 671-675
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238454
- DOI: https://doi.org/10.1007/s10517-017-3684-3
- ID: 238454
如何引用文章
详细
The study established enhanced expression of vascular endothelial growth factor (VEGF) in the subpopulation of osteoblasts located in the regeneration region of femoral bone fracture near the titanium implants with bioactive calcium phosphate and hydroxyapatite coatings and suppressed activity of transforming growth factor-β2 (TGF-β2) in chondroblasts during the two weeks after surgery. In the delayed posttraumatic period, the distribution of TGF-β2 inversely related to its maximal activity. The data revealed the up-regulating effect of bioresorbable coatings on expression of VEGF and TGF-β2 and their implication in the control over various stages of reparative osteogenesis.
作者简介
S. Kalinichenko
Department of Histology, Cytology, and Embryology, Pacific State Medical University; Laboratory of Biomedical Composition Coatings, Institute of Chemistry, Far-East Division of Russian Academy of Sciences
编辑信件的主要联系方式.
Email: sgkalinichenko@gmail.com
俄罗斯联邦, Vladivostok; Vladivostok
N. Matveeva
Department of Histology, Cytology, and Embryology, Pacific State Medical University; Laboratory of Biomedical Composition Coatings, Institute of Chemistry, Far-East Division of Russian Academy of Sciences
Email: sgkalinichenko@gmail.com
俄罗斯联邦, Vladivostok; Vladivostok
R. Kostiv
Department of Histology, Cytology, and Embryology, Pacific State Medical University
Email: sgkalinichenko@gmail.com
俄罗斯联邦, Vladivostok
A. Puz’
Laboratory of Biomedical Composition Coatings, Institute of Chemistry, Far-East Division of Russian Academy of Sciences
Email: sgkalinichenko@gmail.com
俄罗斯联邦, Vladivostok