Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran
- 作者: Drozd N.1, Logvinova Y.1, Torlopov M.2, Udoratina E.2
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隶属关系:
- National Research Center for Hematology, Ministry of Health of the Russian Federation
- Institute of Chemistry, Komi Science Center, Ural Division of the Russian Academy of Sciences
- 期: 卷 162, 编号 4 (2017)
- 页面: 462-465
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238300
- DOI: https://doi.org/10.1007/s10517-017-3640-2
- ID: 238300
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详细
Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.
作者简介
N. Drozd
National Research Center for Hematology, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow
Yu. Logvinova
National Research Center for Hematology, Ministry of Health of the Russian Federation
Email: nndrozd@mail.ru
俄罗斯联邦, Moscow
M. Torlopov
Institute of Chemistry, Komi Science Center, Ural Division of the Russian Academy of Sciences
Email: nndrozd@mail.ru
俄罗斯联邦, Syktyvkar, Komi Republic
E. Udoratina
Institute of Chemistry, Komi Science Center, Ural Division of the Russian Academy of Sciences
Email: nndrozd@mail.ru
俄罗斯联邦, Syktyvkar, Komi Republic