Caspase 3, 6, 8, and 9 Gene Expression in Peripheral Blood Leukocytes and Plasma Concentrations of IL-6 and TNF-α in Carriers of Different Polymorphic Marker -174G>C Genotypes of IL6 Gene Associated with the Risk of Nonalcoholic Steatohepatitis
- 作者: Kurbatova I.1, Topchieva L.1, Dudanova O.2
-
隶属关系:
- Institute of Biology, Karelian Research Center, the Russian Academy of Sciences
- Petrozavodsk State University
- 期: 卷 162, 编号 3 (2017)
- 页面: 370-374
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238216
- DOI: https://doi.org/10.1007/s10517-017-3618-0
- ID: 238216
如何引用文章
详细
We revealed an association of IL6 gene -174G>C polymorphism with the development of nonalcoholic steatohepatitis in the Russian population. The risk is significantly higher in carriers of C allele: OR=1.77 (1.04; 3.02). The effects of -174G>C substitution in IL6 gene involving caspase 9 gene transcripts in peripheral blood leukocytes and on blood content of TNF-α in healthy individuals without clinical manifestations of nonalcoholic steatohepatitis were detected. The content of caspase 9 gene transcripts in peripheral blood leukocytes and plasma level of TNF-α were significantly higher in healthy subjects carrying C allele than in carriers of GG genotype. The levels of caspases 3, 6, 8, and 9 gene transcripts in peripheral blood leukocytes and plasma concentrations of TNF-α in patients with nonalcoholic steatohepatitis did not depend on IL6 genotype by -174G<C marker.
作者简介
I. Kurbatova
Institute of Biology, Karelian Research Center, the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: irina7m@yandex.ru
俄罗斯联邦, Petrozavodsk
L. Topchieva
Institute of Biology, Karelian Research Center, the Russian Academy of Sciences
Email: irina7m@yandex.ru
俄罗斯联邦, Petrozavodsk
O. Dudanova
Petrozavodsk State University
Email: irina7m@yandex.ru
俄罗斯联邦, Petrozavodsk