Caspase 3, 6, 8, and 9 Gene Expression in Peripheral Blood Leukocytes and Plasma Concentrations of IL-6 and TNF-α in Carriers of Different Polymorphic Marker -174G>C Genotypes of IL6 Gene Associated with the Risk of Nonalcoholic Steatohepatitis
- Authors: Kurbatova I.V.1, Topchieva L.V.1, Dudanova O.P.2
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Affiliations:
- Institute of Biology, Karelian Research Center, the Russian Academy of Sciences
- Petrozavodsk State University
- Issue: Vol 162, No 3 (2017)
- Pages: 370-374
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238216
- DOI: https://doi.org/10.1007/s10517-017-3618-0
- ID: 238216
Cite item
Abstract
We revealed an association of IL6 gene -174G>C polymorphism with the development of nonalcoholic steatohepatitis in the Russian population. The risk is significantly higher in carriers of C allele: OR=1.77 (1.04; 3.02). The effects of -174G>C substitution in IL6 gene involving caspase 9 gene transcripts in peripheral blood leukocytes and on blood content of TNF-α in healthy individuals without clinical manifestations of nonalcoholic steatohepatitis were detected. The content of caspase 9 gene transcripts in peripheral blood leukocytes and plasma level of TNF-α were significantly higher in healthy subjects carrying C allele than in carriers of GG genotype. The levels of caspases 3, 6, 8, and 9 gene transcripts in peripheral blood leukocytes and plasma concentrations of TNF-α in patients with nonalcoholic steatohepatitis did not depend on IL6 genotype by -174G<C marker.
About the authors
I. V. Kurbatova
Institute of Biology, Karelian Research Center, the Russian Academy of Sciences
Author for correspondence.
Email: irina7m@yandex.ru
Russian Federation, Petrozavodsk
L. V. Topchieva
Institute of Biology, Karelian Research Center, the Russian Academy of Sciences
Email: irina7m@yandex.ru
Russian Federation, Petrozavodsk
O. P. Dudanova
Petrozavodsk State University
Email: irina7m@yandex.ru
Russian Federation, Petrozavodsk