Regulation of Contractile Responses of Vascular Smooth Muscle Cells under Conditions of Hypoxia—Reoxygenation
- 作者: Gusakova S.1, Birulina Y.1, Smagliy L.1,2, Kovalev I.1, Petrova I.1, Nosarev A.1,2, Orlov S.2
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隶属关系:
- Siberian State Medical University, Ministry of Health of the Russian Federation
- National Research Tomsk Polytechnic University
- 期: 卷 162, 编号 2 (2016)
- 页面: 195-198
- 栏目: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238023
- DOI: https://doi.org/10.1007/s10517-016-3574-0
- ID: 238023
如何引用文章
详细
We analyzed the effects of hypoxia and reoxygenation on changes in contractile activity in rat aortic smooth muscles. Both hypoxia and reoxygenation induced relaxation of smooth muscle cells precontracted with high-potassium Krebs solution (30 mM KCl) or α1-adrenoceptor agonist phenylephrine. Vasodilation resulted from enhancement of potassium permeability of smooth muscle cell membranes caused by activation of voltage-gated potassium channels (triggered by both precontracting agents) or by opening of ATP-sensitive potassium channels (phenylephrine). In isolated smooth muscle cells, both hypoxia and inhibition of Na+,K+-ATPase with ouabain led to depletion of intracellular store of macroergic substances, reduced potassium concentration, and elevated the content of sodium ions.
作者简介
S. Gusakova
Siberian State Medical University, Ministry of Health of the Russian Federation
编辑信件的主要联系方式.
Email: gusacova@yandex.ru
俄罗斯联邦, Tomsk
Yu. Birulina
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: gusacova@yandex.ru
俄罗斯联邦, Tomsk
L. Smagliy
Siberian State Medical University, Ministry of Health of the Russian Federation; National Research Tomsk Polytechnic University
Email: gusacova@yandex.ru
俄罗斯联邦, Tomsk; Tomsk
I. Kovalev
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: gusacova@yandex.ru
俄罗斯联邦, Tomsk
I. Petrova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: gusacova@yandex.ru
俄罗斯联邦, Tomsk
A. Nosarev
Siberian State Medical University, Ministry of Health of the Russian Federation; National Research Tomsk Polytechnic University
Email: gusacova@yandex.ru
俄罗斯联邦, Tomsk; Tomsk
S. Orlov
National Research Tomsk Polytechnic University
Email: gusacova@yandex.ru
俄罗斯联邦, Tomsk