Frequency of 3’ VNTR Polymorphism in the Dopamine Transporter Gene SLC6A3 in Humans Predisposed to Antisocial Behavior
- 作者: Cherepkova E.1, Aftanas L.1, Maksimov N.2,3, Menshanov P.3,4
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隶属关系:
- Research Institute of Physiology and Fundamental Medicine
- Research Institute of Therapy and Preventive Medicine
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk State University
- 期: 卷 162, 编号 1 (2016)
- 页面: 82-85
- 栏目: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/237927
- DOI: https://doi.org/10.1007/s10517-016-3551-7
- ID: 237927
如何引用文章
详细
Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3’ untranslated region (3’ VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3’ VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior.
作者简介
E. Cherepkova
Research Institute of Physiology and Fundamental Medicine
编辑信件的主要联系方式.
Email: india06@mail.ru
俄罗斯联邦, Novosibirsk
L. Aftanas
Research Institute of Physiology and Fundamental Medicine
Email: india06@mail.ru
俄罗斯联邦, Novosibirsk
N. Maksimov
Research Institute of Therapy and Preventive Medicine; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: india06@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
P. Menshanov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk State University
Email: india06@mail.ru
俄罗斯联邦, Novosibirsk; Novosibirsk
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