Frequency of 3’ VNTR Polymorphism in the Dopamine Transporter Gene SLC6A3 in Humans Predisposed to Antisocial Behavior
- Autores: Cherepkova E.1, Aftanas L.1, Maksimov N.2,3, Menshanov P.3,4
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Afiliações:
- Research Institute of Physiology and Fundamental Medicine
- Research Institute of Therapy and Preventive Medicine
- Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk State University
- Edição: Volume 162, Nº 1 (2016)
- Páginas: 82-85
- Seção: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/237927
- DOI: https://doi.org/10.1007/s10517-016-3551-7
- ID: 237927
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Resumo
Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3’ untranslated region (3’ VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3’ VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior.
Sobre autores
E. Cherepkova
Research Institute of Physiology and Fundamental Medicine
Autor responsável pela correspondência
Email: india06@mail.ru
Rússia, Novosibirsk
L. Aftanas
Research Institute of Physiology and Fundamental Medicine
Email: india06@mail.ru
Rússia, Novosibirsk
N. Maksimov
Research Institute of Therapy and Preventive Medicine; Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: india06@mail.ru
Rússia, Novosibirsk; Novosibirsk
P. Menshanov
Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk State University
Email: india06@mail.ru
Rússia, Novosibirsk; Novosibirsk
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