Pro- and Antioxidant Systems in the Lower Portion of Rat Brainstem during Hydroxybutyrate-Induced Pathological Periodic Breathing
- 作者: Tarakanov I.1, Tikhomirova L.1, Zhukova A.2, Safina N.1
-
隶属关系:
- Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology
- Laboratory of Experimental Hygienic Studies, Research Institute for Complex Problems of Hygiene and Occupational Diseases
- 期: 卷 162, 编号 1 (2016)
- 页面: 14-17
- 栏目: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/237865
- DOI: https://doi.org/10.1007/s10517-016-3533-9
- ID: 237865
如何引用文章
详细
Activities of superoxide dismutase and catalase characterizing antioxidant status of the nervous tissue and its resistance to free radical oxidation were measured in the brainstem of rats with hydroxybutyrate-induced pathological periodic breathing. Hydroxybutyrate modified the pro- and antioxidant status in the brainstem respiratory center. It markedly inhibited catalase activity; in rats without the signs of periodic breathing, hydroxybutyrate up-regulated superoxide dismutase activity and to a lesser extent increased the resistance of the membrane structures in the medulla oblongata to induction of free radical oxidation. In rats with periodic breathing pattern, hydroxybutyrate induced more pronounced increase in the sensitivity of membrane structures in the medulla oblongata to induction of free radical oxidation.
作者简介
I. Tarakanov
Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology
编辑信件的主要联系方式.
Email: beta003@rambler.ru
俄罗斯联邦, Moscow
L. Tikhomirova
Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology
Email: beta003@rambler.ru
俄罗斯联邦, Moscow
A. Zhukova
Laboratory of Experimental Hygienic Studies, Research Institute for Complex Problems of Hygiene and Occupational Diseases
Email: beta003@rambler.ru
俄罗斯联邦, Novokuznetsk
N. Safina
Laboratory of General Pathology of Cardiorespiratory System, Research Institute of General Pathology and Pathological Physiology
Email: beta003@rambler.ru
俄罗斯联邦, Moscow