Magnetic Resonance Imaging of Brain Involvement in Dogs Using Paramagnetic Contrast Enhancement with Mn(II)-DCTA P
- 作者: Ussov W.1, Belyanin M.1, Bezlepkin A.1, Borodin O.1, Bobrikova E.1, Shimanovskii N.2
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隶属关系:
- Research Institute of Cardiology
- N. I. Pirogov Russian Research Medical University
- 期: 卷 161, 编号 5 (2016)
- 页面: 715-718
- 栏目: Experimental Methods for Clinical Practice
- URL: https://journals.rcsi.science/0007-4888/article/view/237706
- DOI: https://doi.org/10.1007/s10517-016-3492-1
- ID: 237706
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详细
Experimental study of a new paramagnetic complex Mn-DCTA is carried out. The complex (0.5 M manganese(II) solution with trans-1,2-diamine cyclohexane-N,N,N’,N’-tetraacetic acid; Cyclomang) was used for contrast magnetic resonance imaging visualization of CNS involvement in dogs with severe forms of Babesia canis infection. CNS injuries were visualized in all cases, with highly intense contrasting at the expense of Mn-DCTA accumulation at the periphery of the damaged zone. Quantitative evaluation of the paramagnetic accumulation in the focus showed that the amplification index wa s 1.19±0.11 for the central areas and 1.47±0.17 for the peripheral ones. The pituitary (1.18±0.05) and vascular plexuses of the lateral ventricles (1.12±0.09) were also contrasted. Injection of the paramagnetic to dogs was not associated with any kinds of pathological or physiological reactions. Mn-DCTA complex allowed contrast visualization of the focal injuries to the CNS and could be regarded as a paramagnetic contrast agent for magnetic resonance imaging of brain injuries in dogs.
作者简介
W. Ussov
Research Institute of Cardiology
Email: mritomsk@yandex.ru
俄罗斯联邦, Tomsk
M. Belyanin
Research Institute of Cardiology
Email: mritomsk@yandex.ru
俄罗斯联邦, Tomsk
A. Bezlepkin
Research Institute of Cardiology
Email: mritomsk@yandex.ru
俄罗斯联邦, Tomsk
O. Borodin
Research Institute of Cardiology
Email: mritomsk@yandex.ru
俄罗斯联邦, Tomsk
E. Bobrikova
Research Institute of Cardiology
Email: mritomsk@yandex.ru
俄罗斯联邦, Tomsk
N. Shimanovskii
N. I. Pirogov Russian Research Medical University
编辑信件的主要联系方式.
Email: mritomsk@yandex.ru
俄罗斯联邦, Moscow